(optimal receptivity analysis)
Non-Invasive Endometrial Receptivity Analysis Test
What is the ORA™ Test?
The ORA™ test (Non-Invasive ERA) evaluates the endometrial receptivity status by identifying the optimal window of implantation (WOI).
Using a non-invasive approach, the ORA™ test analyzes the expression patterns of 281 microRNAs (miRNAs) in the blood.
Through a single test utilizing advanced next-generation sequencing (NGS) technology, the ORA™ provides over 95% accuracy with less than a 1% retesting rate.
This test helps to improve embryo implantation success rates and increases the likelihood of successful outcomes in IVF treatment cycles.
Indications for Testing
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Anyone seeking a personalized optimal embryo transfer window
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Individuals planning for early pregnancy due to infertility
or advanced maternal age -
Cases of unexplained recurrent implantation failure (RIF)
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Individuals who experienced chemical pregnancy after embryo transfer
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Cases with a limited number of high-grade embryos
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Those who prefer a safe, non-invasive blood test over an invasive endometrial biopsy
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Individuals with a history of test failure due to thin endometrium
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Those concerned about implantation due to high or low body mass index (BMI)
TestingProcess
Blood samples are collected either during a hormone replacement
therapy (HRT) cycle or a natural cycle.
In an HRT cycle, blood is drawn at 96 hours (Day 4) and 120 hours (Day 5) after
progesterone (P4) administration.
In a natural cycle, blood is collected at 144 hours (Day 6) and 168 hours (Day 7) after
a luteinizing hormone (LH) surge or human chorionic gonadotropin (hCG) administration.
The exact timing for blood collection may be adjusted based on the physician’s
evaluation and treatment plan.
The collected blood sample is sent to the laboratory for RNA extraction and analysis.
Based on the results, a personalized embryo transfer schedule is designed for the next treatment cycle.
Result Confirmation
and Interpretation
The test results help determine the optimal timing for embryo transfer, which can improve the chances of a successful
pregnancy during the next IVF cycle.
The results are categorized as follows and provided to the patient
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Receptive: This is the most optimal time for embryo transfer.
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Pre-Receptive: It is recommended to delay the embryo transfer by 24 hours in the next cycle.
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Post-Receptive: It is recommended to move the embryo transfer forward by 12 to 24 hours in the next cycle.